PTDSS1 serves as a prognostic biomarker of macrophage infiltration in pan-cancer and promotes hepatocellular carcinoma malignant phenotypes
Chenlu Lan, Zuyin Wan, Haifei Qin, Haixiang Xie, Yu Chen, Chongjiu Qin, Zhongliu Wei, Yongguang Wei, Xin Zhou, Wei Qin, Guangzhi Zhu, Tao Peng · 2025
Read PTDSS1 serves as a prognostic biomarker of macrophage infiltration in pan-cancer and promotes hepatocellular carcinoma malignant phenotypes by Chenlu Lan, Zuyin Wan, Haifei Qin, Haixiang Xie, Yu Chen, Chongjiu Qin, Zhongliu Wei, Yongguang Wei, Xin Zhou, Wei Qin, Guangzhi Zhu, Tao Peng (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12752422.txt.
Description
Chenlu Lan and co-authors study a gene called PTDSS1 across cancers in a 2025 paper. The gene builds part of cell membranes, and a drug that blocks it has shown early promise against tumors. Yet the gene's wider role in cancer was little mapped. The team asked where it runs high, what that predicts, and whether it feeds tumor growth.
Across most cancer types, the gene was switched on more strongly in tumors than in healthy tissue, and high levels went with poorer survival in seven cancers. Extra gene copies and chemical marks on the gene may drive the rise. In samples from seventy-four liver cancer patients, and in lab cells, dialing the gene down blunted the cancer's aggressive traits. The gene also tracked how many immune macrophages enter tumors, making it a candidate marker and target.
Catalog record
| CREATOR | Chenlu Lan, Zuyin Wan, Haifei Qin, Haixiang Xie, Yu Chen, Chongjiu Qin, Zhongliu Wei, Yongguang Wei, Xin Zhou, Wei Qin, Guangzhi Zhu, Tao Peng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |