Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models
Tingting Mo, Yue Qiu, Shuangshuang He, Guibin Wang, Bingbing Li, Qian Shen, Xiaowei Nie, Jiali Wei, Nachuan Li, Bo Pang, Yanfeng Liu, Xue Pan · 2025
Read Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models by Tingting Mo, Yue Qiu, Shuangshuang He, Guibin Wang, Bingbing Li, Qian Shen, Xiaowei Nie, Jiali Wei, Nachuan Li, Bo Pang, Yanfeng Liu, Xue Pan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12752370.txt.
Description
Tingting Mo and co-authors wrote a 2025 paper on how long-term stress may worsen polycystic ovary syndrome, a hormone disorder that affects fertility and metabolism. Stress and this syndrome often appear together, but the link between them is not understood. The team focused on kisspeptin, a protein that helps control both reproduction and energy use.
They measured blood levels in twenty-seven women with the syndrome and eleven without it. In parallel, they ran rat groups that separated the syndrome, stress, and both together. They tracked behavior, hormone function, blood sugar handling, and cell death in the ovary. The paired human and animal work aims to show whether this protein carries the effect of stress into the syndrome's core problems.
Catalog record
| CREATOR | Tingting Mo, Yue Qiu, Shuangshuang He, Guibin Wang, Bingbing Li, Qian Shen, Xiaowei Nie, Jiali Wei, Nachuan Li, Bo Pang, Yanfeng Liu, Xue Pan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |