Differential roles of coding and non-coding transcripts in obesity: insights from RNA-seq analysis of Macaca fascicularis hepatocytes
Yu Liu, Ziting Wang, Linna Liu, Ya Tan, Wenling Zheng, Pengfei Zhang, Andrew P Hutchins, Leonard Lipovich, Weizhong Wang · 2025
Read Differential roles of coding and non-coding transcripts in obesity: insights from RNA-seq analysis of Macaca fascicularis hepatocytes by Yu Liu, Ziting Wang, Linna Liu, Ya Tan, Wenling Zheng, Pengfei Zhang, Andrew P Hutchins, Leonard Lipovich, Weizhong Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12752347.txt.
Description
Yu Liu and co-authors published a 2025 study on gene activity in the livers of monkeys with obesity-related diabetes. The monkeys, cynomolgus macaques, are close models of human metabolism. The team read out which genes were active in liver cells from diabetic and healthy animals. They paid special attention to long non-coding RNAs, stretches of RNA that regulate other genes without making proteins.
Protein-coding and non-coding RNAs showed distinct patterns between the groups. The coding genes clustered in metabolic pathways, above all in fat transport. Genes for breaking down alcohol were turned down in the diabetic livers. The non-coding RNAs followed their own separate pattern, hinting they help steer the metabolic changes. The study widens the molecular picture of how obesity leads toward diabetes. The authors suggest the patterns could guide precision treatments aimed at specific RNA targets in the liver.
Catalog record
| CREATOR | Yu Liu, Ziting Wang, Linna Liu, Ya Tan, Wenling Zheng, Pengfei Zhang, Andrew P Hutchins, Leonard Lipovich, Weizhong Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |