Bacteroides fragilis colonization induces protective systemic IgA
Joshua R. Harris, Nicole Gubitosi, Victoria Zoccoli-Rodriguez, Kayla M. Borg, Mara S. Delaney, Tania N. Cruz, Brian T. Gaudette, Joel R. Wilmore · 2025
Read Bacteroides fragilis colonization induces protective systemic IgA by Joshua R. Harris, Nicole Gubitosi, Victoria Zoccoli-Rodriguez, Kayla M. Borg, Mara S. Delaney, Tania N. Cruz, Brian T. Gaudette, Joel R. Wilmore (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12752218.txt.
Description
Joshua Harris and co-authors show how a common gut bacterium can raise protective antibody levels through the whole body. The bacterium is Bacteroides fragilis, a normal gut resident known to prompt mucosal IgA. Less was known about what prompts IgA that spreads into blood and bone marrow.
In their 2025 study, strong gut colonization was needed for bone marrow plasma cells and high serum IgA aimed at the bacterium. Mice without Peyer's patches lost most of this response, while loss of the cecal patch did not. The serum IgA then protected mice from abscesses after the bacterium spread in a bowel perforation model. The work ties colonization and patch contact to broad protection.
Catalog record
| CREATOR | Joshua R. Harris, Nicole Gubitosi, Victoria Zoccoli-Rodriguez, Kayla M. Borg, Mara S. Delaney, Tania N. Cruz, Brian T. Gaudette, Joel R. Wilmore |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |