Cannabinoid receptor 2 affect the inflammatory response in periodontitis by regulating macrophage M1/M2 polarization
Shu-Yue Yuan, Fei Zhao, Ran Tao, Bing Liu, Chun-Yan Liu · 2025
Read Cannabinoid receptor 2 affect the inflammatory response in periodontitis by regulating macrophage M1/M2 polarization by Shu-Yue Yuan, Fei Zhao, Ran Tao, Bing Liu, Chun-Yan Liu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12752204.txt.
Description
Shu-Yue Yuan and co-authors present a 2025 study on gum disease and a receptor called CB2R. Periodontitis is a chronic gum infection that destroys the tissue and bone holding teeth. Immune cells called macrophages drive much of that damage, and they can lean toward attack or repair modes.
The team induced gum disease in normal mice and in mice lacking the CB2R gene. After three weeks they measured bone loss, tissue damage, and immune cell markers. Mice without the receptor lost more bone and showed worse tissue destruction than normal mice with the disease. Their macrophage balance also shifted. The findings suggest CB2R helps steer macrophages toward a calmer mode. That makes the receptor a possible drug target for gum disease.
Catalog record
| CREATOR | Shu-Yue Yuan, Fei Zhao, Ran Tao, Bing Liu, Chun-Yan Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |