Molecular regulatory network of glycolytic reprogramming in hepatocellular carcinoma and its clinical implications
Hengzhou Zhu, Jiahui Li, Jiaying Zhang, Dong Niu, Weiwang Zheng, Chunhui Jin · 2025
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Description
Six reviewers map the control network that pushes liver cancer cells to burn sugar in a wasteful way. Liver cancer is among the most common and deadly cancers, and its cells favor glycolysis, splitting glucose into lactate even when oxygen is plentiful. That Warburg effect feeds growth with energy and building blocks while souring and stressing the tissue around the tumor.
The review walks through the layers of control: the genes switched on or off, chemical edits that tune the sugar-burning enzymes after they are made. It also covers the small and large non-coding RNAs that adjust the machinery. It then turns to the master signaling pathways and the influence of the tumor's neighborhood, where nearby cells trade signals that reshape metabolism. The authors close with the clinical side, including scans that image sugar use, and the hope that cutting this fuel line could slow the disease.
Catalog record
| CREATOR | Hengzhou Zhu, Jiahui Li, Jiaying Zhang, Dong Niu, Weiwang Zheng, Chunhui Jin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |