Involvement of α7nAChR in the hepatic-protective effect of remifentanil preconditioning in ischemia/reperfusion rats
Chaoxiong Zhou, Yuan Ma, Da Qiu, Qianjin He, Qinshu Xiao, Yaohua Wu, Quanshui Hao, Huaping Wang · 2025
Read Involvement of α7nAChR in the hepatic-protective effect of remifentanil preconditioning in ischemia/reperfusion rats by Chaoxiong Zhou, Yuan Ma, Da Qiu, Qianjin He, Qinshu Xiao, Yaohua Wu, Quanshui Hao, Huaping Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12751796.txt.
Description
Chaoxiong Zhou and colleagues tested whether the anesthetic remifentanil protects the liver from the damage that follows when blood flow is cut and then restored, a routine hazard of liver surgery. Earlier work showed the drug helps, but the route was unknown. Writing in twenty twenty-five, the team used rats with liver blood flow interruption and liver cells stressed by low oxygen in the dish. A brief drug dose before the insult was the test treatment, and damage, cell death, and inflammation were measured in tissue and cells.
Pre-treatment plainly eased liver dysfunction, reduced cell death, and quieted inflammation. It also raised levels of a nicotine-type receptor on cells while blocking activation of a master inflammation switch. Blocking or removing that receptor erased the protection. The authors identify the receptor pathway as the mechanism behind the drug liver benefit.
Catalog record
| CREATOR | Chaoxiong Zhou, Yuan Ma, Da Qiu, Qianjin He, Qinshu Xiao, Yaohua Wu, Quanshui Hao, Huaping Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |