Dissecting the effect of long-term exposure to air pollution on risk of dementia in UK Biobank
Ensor Rafael Palacios, Chin Yang Shapland, Levi John Wolf, Liv Tybjærg Nordestgaard, Emma Anderson, Chloe Slaney, Dan Bernie, Dann Mitchell, Patrick Gavin Kehoe, Gareth James Griffith, Kate Tilling · 2025
Read Dissecting the effect of long-term exposure to air pollution on risk of dementia in UK Biobank by Ensor Rafael Palacios, Chin Yang Shapland, Levi John Wolf, Liv Tybjærg Nordestgaard, Emma Anderson, Chloe Slaney, Dan Bernie, Dann Mitchell, Patrick Gavin Kehoe, Gareth James Griffith, Kate Tilling (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12751783.txt.
Description
Ensor Rafael Palacios and ten colleagues dissected how long-term air pollution exposure relates to dementia in the UK Biobank. Evidence linking dirty air to dementia keeps mounting, but causal reading is tricky. The team modeled several particle types and nitrogen oxides, individually and together. They confronted three obstacles head-on: neighborhood-level confounding, overlapping pollutants that blur which one matters, and uncertainty about the exposure window that counts.
Control analyses used a lung disease as a positive control and oily fish intake as a negative one. Nitrogen dioxide emerged as the strongest risk factor for dementia. The signal strengthened in people who had lived longest at one address, a proxy for longer exposure. The twenty twenty-five analysis sharpens which pollutant policy should target first to protect aging brains.
Catalog record
| CREATOR | Ensor Rafael Palacios, Chin Yang Shapland, Levi John Wolf, Liv Tybjærg Nordestgaard, Emma Anderson, Chloe Slaney, Dan Bernie, Dann Mitchell, Patrick Gavin Kehoe, Gareth James Griffith, Kate Tilling |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |