Human umbilical cord mesenchymal stem cells attenuate liver fibrosis in mice and inhibit hepatic stellate cell activation by secreting soluble factors
Qi Zhou, Junyu Wang, Ke Cheng, Ruyi Mei, Janette Heegsma, Han Moshage, Martin C. Harmsen, Klaas Nico Faber, Pingnan Sun · 2025
Read Human umbilical cord mesenchymal stem cells attenuate liver fibrosis in mice and inhibit hepatic stellate cell activation by secreting soluble factors by Qi Zhou, Junyu Wang, Ke Cheng, Ruyi Mei, Janette Heegsma, Han Moshage, Martin C. Harmsen, Klaas Nico Faber, Pingnan Sun (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12751779.txt.
Description
BackgroundMesenchymal stem cells (MSCs) have emerged as promising candidates to treat clinical liver fibrosis. However, the key factors and mechanisms underlying their antifibrotic effects remain largely unclear. Our aims were to assess the therapeutic efficacy of human umbilical cord (UC) MSCs in a murine liver fibrosis model, and to dissect the influence of their secretome in vitro.
Catalog record
| CREATOR | Qi Zhou, Junyu Wang, Ke Cheng, Ruyi Mei, Janette Heegsma, Han Moshage, Martin C. Harmsen, Klaas Nico Faber, Pingnan Sun |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |