Mediating effects of maternal blood lipids and glucose on the relationship between pre-pregnancy body mass index and newborn birth weight in women with gestational diabetes mellitus
Hanbing Li, Zhixuan Xiang, Hui Li, Chenxi Xie, Zeng Li, Yingni Liang, Lingling Gao, Zhongyu Li · 2025
Read Mediating effects of maternal blood lipids and glucose on the relationship between pre-pregnancy body mass index and newborn birth weight in women with gestational diabetes mellitus by Hanbing Li, Zhixuan Xiang, Hui Li, Chenxi Xie, Zeng Li, Yingni Liang, Lingling Gao, Zhongyu Li (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12751765.txt.
Description
Li and co-authors asked how a mother's weight before pregnancy ends up affecting her baby's birth weight when she has gestational diabetes. They reviewed records for 1,257 women treated at a Guangzhou hospital between 2017 and 2021. Blood fats were measured at the first prenatal visit, and blood sugar was tested in mid-pregnancy. The team used mediation analysis to see how much of the weight effect runs through those blood measures.
Higher pre-pregnancy body mass index raised birth weight directly, but part of the effect traveled through the blood. One path ran through lower early-pregnancy HDL cholesterol, another through higher mid-pregnancy fasting glucose, and a small chain ran through both in sequence. Together the indirect paths made up about a fifth of the total effect. The authors say watching lipids and glucose may help manage birth weight in diabetic pregnancies.
Catalog record
| CREATOR | Hanbing Li, Zhixuan Xiang, Hui Li, Chenxi Xie, Zeng Li, Yingni Liang, Lingling Gao, Zhongyu Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |