FGFR1 and FGFR4 are essential regulators of muscle stem cell quiescence
Chung-Ju Yeh, Kiran Nakka, Zipora Yablonka-Reuveni, Christoph Lepper · 2025
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Description
Chung-Ju Yeh, Kiran Nakka, Zipora Yablonka-Reuveni, and Christoph Lepper show two receptors keep muscle stem cells at rest, in work from 2025. Rest state guards the long life of adult stem cells and tissue repair power. Loss of rest with age drains the stem pool and weakens healing after injury.
Satellite cells that lack both growth receptors leave rest too early in mice. Those cells rush into final muscle form and fail to renew the pool. Muscle repair after injury also weakens when both receptors are gone. A growth signal path inside the cell drives that early exit from rest. The pair may serve as drug targets to lift muscle repair.
Catalog record
| CREATOR | Chung-Ju Yeh, Kiran Nakka, Zipora Yablonka-Reuveni, Christoph Lepper |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |