Quantification and impact of circulating cardiotonic steroids in the RATE-AF randomised trial of patients with atrial fibrillation and heart failure
Ioannis Akoumianakis, Lorna C Gilligan, Karina V Bunting, Dannie Fobian, Paulus Kirchhof, Wiebke Arlt, Angela E Taylor, Davor Pavlovic, Dipak Kotecha, Rate control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) trial team · 2025
Read Quantification and impact of circulating cardiotonic steroids in the RATE-AF randomised trial of patients with atrial fibrillation and heart failure by Ioannis Akoumianakis, Lorna C Gilligan, Karina V Bunting, Dannie Fobian, Paulus Kirchhof, Wiebke Arlt, Angela E Taylor, Davor Pavlovic, Dipak Kotecha, Rate control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) trial team (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12751528.txt.
Description
Ioannis Akoumianakis and co-authors measure heart active steroids in a trial of rhythm and heart failure patients in a 2025 study. The body may make its own digoxin like compounds, but their presence in humans is disputed. A new lab pipeline can now count them with high precision.
All 160 trial patients took part, with a mean age of 76 and 46% women. Two body made compounds were found and counted in entry samples, with eight more at trace levels. Patients put on digoxin fared better at 12 months on heart failure class than those on beta blockers. The gap was clear on the standard scale used in the trial. Links between the body made compounds and drug action are probed in the data.
Catalog record
| CREATOR | Ioannis Akoumianakis, Lorna C Gilligan, Karina V Bunting, Dannie Fobian, Paulus Kirchhof, Wiebke Arlt, Angela E Taylor, Davor Pavlovic, Dipak Kotecha, Rate control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) trial team |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |