Differential TGF-β1/SMAD4 Signaling Regulates PMN-MDSC Differentiation and Reshapes the Immune Microenvironment in Breast Cancer
Jie Cao, Enqi Qiao, Hui Shao, Chunlei Wang, Manzhi Xia, Bo Qin · 2025
Read Differential TGF-β1/SMAD4 Signaling Regulates PMN-MDSC Differentiation and Reshapes the Immune Microenvironment in Breast Cancer by Jie Cao, Enqi Qiao, Hui Shao, Chunlei Wang, Manzhi Xia, Bo Qin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12751383.txt.
Description
Jie Cao and co-authors trace how a growth signal decides the fate of immune-suppressing cells in breast cancer. These suppressor cells blunt the body's attack on the tumor and track with poor outcomes, but what creates them was unclear. Combining single-cell and location-based gene reading in tumor tissue with a mouse model of spreading breast cancer, the team followed the signal TGF-β1 and its partner SMAD4 along the cells' development path.
Raising the signal pushed stem cells toward the suppressor type and sped colony growth in healthy mice — yet in tumor-bearing mice the same move had the opposite effect. The authors conclude the pathway steers these cells differently depending on whether cancer is present, which reshapes the tumor's immune setting.
Catalog record
| CREATOR | Jie Cao, Enqi Qiao, Hui Shao, Chunlei Wang, Manzhi Xia, Bo Qin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |