Polymorphism-driven transcriptomic changes in anthelmintic metabolism pathways of Anisakis simplex s.s. L3 larvae
Mateusz Maździarz, Iwona Polak, Lukasz Paukszto, Monika Szczecińska, Elżbieta Łopieńska-Biernat · 2025
Read Polymorphism-driven transcriptomic changes in anthelmintic metabolism pathways of Anisakis simplex s.s. L3 larvae by Mateusz Maździarz, Iwona Polak, Lukasz Paukszto, Monika Szczecińska, Elżbieta Łopieńska-Biernat (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12751375.txt.
Description
Mateusz Maździarz and co-authors studied how a parasitic worm responds to deworming drugs in 2025. The worm, Anisakis simplex, spreads to people through eaten fish and can cause allergy as well as illness. How its genes react to drug treatment was poorly known.
Young larvae were exposed to three common drugs: albendazole, ivermectin, and pyrantel. Gene activity, splicing changes, and sequence variants were all measured. Each drug left a distinct mark. One changed genes tied to the worm's outer coat, one drove wide splicing changes in immune paths, and one linked to many variants in nerve and metabolism genes. The results map drug-specific responses that may bear on drug resistance.
Catalog record
| CREATOR | Mateusz Maździarz, Iwona Polak, Lukasz Paukszto, Monika Szczecińska, Elżbieta Łopieńska-Biernat |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |