Minimum Effective Volume of Liposomal Bupivacaine for Interscalene Block in Arthroscopic Rotator Cuff Repair: A Prospective, Biased-Coin Up-and-Down Dose-Finding Study
Hai-Tao Wang, Qiong Xue, Hui-Juan Li, Ying-Ying Zhao, Ke Tian, Jian-Jun Yang · 2025
Read Minimum Effective Volume of Liposomal Bupivacaine for Interscalene Block in Arthroscopic Rotator Cuff Repair: A Prospective, Biased-Coin Up-and-Down Dose-Finding Study by Hai-Tao Wang, Qiong Xue, Hui-Juan Li, Ying-Ying Zhao, Ke Tian, Jian-Jun Yang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12751346.txt.
Description
Hai-Tao Wang and five colleagues hunted for the smallest dose of a long-acting numbing drug that still blocks pain well after shoulder surgery. The drug, liposomal bupivacaine, is placed near the nerves of the neck to numb the arm. Too little fails; too much adds risk. Fifty-one patients having keyhole repair of a torn shoulder tendon took part. Each got a dose set by the last patient's result, in a biased-coin up-and-down plan.
The dose that worked for nine in ten patients came out at 10.0 milliliters, with a likely range of 9.3 to 12.5. Side effects were logged for three days after surgery. A firm number like this helps surgical teams standardize the block instead of guessing. The twenty twenty-five study turns a habit-based choice into a measured one for a common operation.
Catalog record
| CREATOR | Hai-Tao Wang, Qiong Xue, Hui-Juan Li, Ying-Ying Zhao, Ke Tian, Jian-Jun Yang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |