The Landscape of Potential Targeted Treatments and Chemotherapy Efficacy Biomarkers for TNBC
Yujuan Kang, Yanqing Liu, Zhi Liang, Song Zhang, Guangdong Qiao · 2025
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Description
Yujuan Kang and four co-authors survey the hunt for targeted treatments for triple-negative breast cancer in this 2025 review. The disease lacks the three receptors that standard targeted drugs aim at, spreads early, and often shrugs off chemotherapy. Its inner workings are unusually tangled, with many mutated genes and signaling networks stuck in the on position.
The review first walks through the known subtypes of the disease and its abnormal gene activity and signaling. It then gathers the targeted drugs matched to those flaws, including therapies already in clinical trials. A detailed list follows of genes tied to whether chemotherapy works or fails, offered as possible indicators of how a patient will respond. The authors close with new and future treatment ideas. Their aim is a map of which patients are most likely to benefit from chemotherapy and from the coming wave of targeted options.
Catalog record
| CREATOR | Yujuan Kang, Yanqing Liu, Zhi Liang, Song Zhang, Guangdong Qiao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |