Preliminary Developmental Safety Assessment of Allylestrenol in Pregnant SD Rats: Evaluation of F0 and Early F1 Generational Endpoints
Lai Jiang, Shengnan Zhuan, Wenjie Jin, He Wen, Dajin Li · 2025
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Description
Allylestrenol is given to support pregnancies at risk, yet its safety for the developing young needs direct testing. Lai Jiang and co-authors run a preliminary study in pregnant rats. One hundred thirty-eight mated females received the drug at three dose levels, or control treatments including standard progesterone forms. The team tracked hormone levels in the mothers. They then followed the pups' early development.
The highest dose lowered estradiol late in pregnancy. Two lower doses raised testosterone compared with controls. A standard marker of developmental disruption, the anogenital distance in pups, showed no change at any dose. The authors present the work as a first pass: the drug leaves most measured endpoints alone, but the hormone shifts at higher doses mark where closer study should look.
Catalog record
| CREATOR | Lai Jiang, Shengnan Zhuan, Wenjie Jin, He Wen, Dajin Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |