Three Conformations of Polyglutamic Acid Monitored by Vibrational Optical Activity
Andrii S. Kurochka, Jana Hudecová, Josef Kapitán, Jiří Kessler, Petr Bouř · 2025
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Description
Kurochka, Hudecová, Kapitán, Kessler, and Bouř track in twenty twenty-five three shapes taken by a simple chain molecule used to study protein folding. The chain, made of one repeated amino acid, changes shape with its acid state. The team read those shapes with light-based methods that sense how the molecule twists and vibrates.
They recorded several kinds of spectra for each form, including fibres that clump like those seen in brain diseases. Computer models of the moving molecule let them link each spectrum to a shape. The fibre form gave a distinct pattern, checked by testing its mirror twin. The authors say the paired approach can help study protein clumps tied to disease.
Catalog record
| CREATOR | Andrii S. Kurochka, Jana Hudecová, Josef Kapitán, Jiří Kessler, Petr Bouř |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |