NHE1 in macrophages promotes octanal/Olfr2-induced atherosclerosis via calcium-dependent ROS and NLRP3 inflammasome activation
Tianhui Wang, Lan Wang, Qian Tian, Yuan Zhu, Lijuan Shao, Jiao Zeng, Yongchao Yu, Zhonglian Li, Xiaomeng Su, Juhai Chen, Ya Zhang, Xiangang Mo · 2025
Read NHE1 in macrophages promotes octanal/Olfr2-induced atherosclerosis via calcium-dependent ROS and NLRP3 inflammasome activation by Tianhui Wang, Lan Wang, Qian Tian, Yuan Zhu, Lijuan Shao, Jiao Zeng, Yongchao Yu, Zhonglian Li, Xiaomeng Su, Juhai Chen, Ya Zhang, Xiangang Mo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12749899.txt.
Description
Tianhui Wang and eleven co-authors traced a pathway by which a scent compound worsens artery clogging in twenty twenty-five. The compound, octanal, acts on a smell receptor found in plaque macrophages, the immune cells inside artery deposits. Both that receptor and a sodium-hydrogen exchanger called NHE1 run high in plaques, but their link was unclear. The team used mice prone to the disease and a macrophage cell line.
Octanal injections worsened clogging and raised NHE1 in plaques, while mice lacking NHE1 formed less plaque and less inflammation. In cells, octanal raised NHE1 amount and activity, feeding foam cell growth and swelling signals, and blocker drugs blunted all of it. Silencing the receptor, or tying up calcium, cut the NHE1 rise. The authors name NHE1 as the key downstream actor and a hopeful drug target.
Catalog record
| CREATOR | Tianhui Wang, Lan Wang, Qian Tian, Yuan Zhu, Lijuan Shao, Jiao Zeng, Yongchao Yu, Zhonglian Li, Xiaomeng Su, Juhai Chen, Ya Zhang, Xiangang Mo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |