Proton pump inhibitors have no effect on short or long term rebleeding or mortality in patients with overt gastrointestinal bleeding
Jamil Mrad, Ali Elhadi Zreik, Chantal Rizk, Reem Mansour, Hani Tamim, Walaa G El Sheikh, Ala’ I Sharara, Fadi H Mourad, Fady Daniel, Assaad Soweid, Yasser H Shaib, Noelle El Asmar, Don C Rockey, Kassem A Barada · 2025
Read Proton pump inhibitors have no effect on short or long term rebleeding or mortality in patients with overt gastrointestinal bleeding by Jamil Mrad, Ali Elhadi Zreik, Chantal Rizk, Reem Mansour, Hani Tamim, Walaa G El Sheikh, Ala’ I Sharara, Fadi H Mourad, Fady Daniel, Assaad Soweid, Yasser H Shaib, Noelle El Asmar, Don C Rockey, Kassem A Barada (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12749860.txt.
Description
Jamil Mrad and thirteen co-authors check whether acid-blocking drugs help patients with gut bleeding, in a 2025 study. These drugs, called proton pump inhibitors, are widely used in such cases, yet their real benefit was unclear.
The team followed 846 patients admitted with gut bleeding at a major center from 2013 to 2023. Use of the drugs was often off-guideline: about half of patients got them without need on arrival, while a quarter who needed them left without them. Drug users showed fewer fresh bleeding signs and needed less scope treatment. But their death and rebleeding rates matched non-users, both at one month and over the long follow-up. Signs of recent bleeding and severe bleeding best predicted who would bleed again.
Catalog record
| CREATOR | Jamil Mrad, Ali Elhadi Zreik, Chantal Rizk, Reem Mansour, Hani Tamim, Walaa G El Sheikh, Ala’ I Sharara, Fadi H Mourad, Fady Daniel, Assaad Soweid, Yasser H Shaib, Noelle El Asmar, Don C Rockey, Kassem A Barada |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |