Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses
Paul Lapios, Robin Anger, Vincent Paget-Blanc, Esther Marza, Vladan Lučić, Rémi Fronzes, Etienne Herzog, David Perrais · 2025
Read Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses by Paul Lapios, Robin Anger, Vincent Paget-Blanc, Esther Marza, Vladan Lučić, Rémi Fronzes, Etienne Herzog, David Perrais (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12749485.txt.
Description
Paul Lapios and co-authors image dopamine release hubs in mouse striatum at frozen nanoscale detail. Dopamine tunes reward and movement through dense wiring in the striatum. Release buds from dopamine axons park beside ordinary synapses, forming hub arrangements. Cryo light and electron tomography froze those hubs for close reading.
Dopamine buds held about ten times fewer vesicles than glutamate terminals. Their vesicles ran bigger and less round as well. Most glutamate terminals kept primed vesicles ready to fire. Only about a third of dopamine buds held tethered vesicles, none clearly primed. Partner synapses beside the hubs carried extra primed vesicles, hinting at local tuning.
Catalog record
| CREATOR | Paul Lapios, Robin Anger, Vincent Paget-Blanc, Esther Marza, Vladan Lučić, Rémi Fronzes, Etienne Herzog, David Perrais |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |