A single-dose mRNA vaccine protects mice from lethal Crimean-Congo hemorrhagic fever virus infection
Juhong Rao, Jin Li, Tingting Jiang, Weiwei Guo, Xuekai Zhang, Zihan Zhang, Jiaoling Su, Mingqing Lu, Xue Hu, Xingpo Liu, Rong Qu, Tao Zhu, Chenlong Hu, Kunpeng Liu, Haomeng Wang, Chao Shan · 2025
Read A single-dose mRNA vaccine protects mice from lethal Crimean-Congo hemorrhagic fever virus infection by Juhong Rao, Jin Li, Tingting Jiang, Weiwei Guo, Xuekai Zhang, Zihan Zhang, Jiaoling Su, Mingqing Lu, Xue Hu, Xingpo Liu, Rong Qu, Tao Zhu, Chenlong Hu, Kunpeng Liu, Haomeng Wang, Chao Shan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12749442.txt.
Description
Juhong Rao and fifteen co-authors report an mRNA vaccine that shields mice from a deadly tick-borne virus. The virus causes Crimean-Congo hemorrhagic fever, which kills between about 3 and 30 percent of patients. It spreads across parts of Asia, Europe, and Africa, and no licensed vaccine exists yet.
The team built vaccines carrying code for two virus proteins, the inner core protein and the surface coat. The core-protein vaccine alone fully protected mice against a lethal dose, even from a different strain. A single shot of just two micrograms was enough. Blood serum from vaccinated mice also gave partial protection when transferred. The results support fast vaccine work ahead of outbreaks.
Catalog record
| CREATOR | Juhong Rao, Jin Li, Tingting Jiang, Weiwei Guo, Xuekai Zhang, Zihan Zhang, Jiaoling Su, Mingqing Lu, Xue Hu, Xingpo Liu, Rong Qu, Tao Zhu, Chenlong Hu, Kunpeng Liu, Haomeng Wang, Chao Shan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |