Computational screening and molecular modeling of probiotic-derived peptides targeting the conserved HR1 domain of SARS-CoV-2 spike protein
Alireza Sattar, Bahar Saadaie Jahromi, Fatemeh Sadat Jalilzadeh Ghahi, Golsa Nayeb Ghanbar Hoseini, Najaf Allahyari Fard · 2025
Read Computational screening and molecular modeling of probiotic-derived peptides targeting the conserved HR1 domain of SARS-CoV-2 spike protein by Alireza Sattar, Bahar Saadaie Jahromi, Fatemeh Sadat Jalilzadeh Ghahi, Golsa Nayeb Ghanbar Hoseini, Najaf Allahyari Fard (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12749439.txt.
Description
Alireza Sattar and co-authors published a computing study in 2025 on blocking the COVID-19 virus with germ-made peptides. The virus enters cells when its spike protein fuses with the cell wall. A conserved spike segment drives that fusion, making it a tempting drug target that varies little across strains.
The team screened 318 peptides from probiotic germs in simulation. Docking tests, safety filters, and motion simulations narrowed the field. One peptide bound the fusion segment tightly across all tested variants, from early strains to recent ones. It also passed screens for toxicity, allergy, and blood harm. Simulated binding stayed stable over time. The authors call it a broad candidate antiviral, while noting lab proof is still needed.
Catalog record
| CREATOR | Alireza Sattar, Bahar Saadaie Jahromi, Fatemeh Sadat Jalilzadeh Ghahi, Golsa Nayeb Ghanbar Hoseini, Najaf Allahyari Fard |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |