Precision dosing of recombinant vaccinia vaccine via pillar-guided microneedle patch confers SARS-CoV-2 immunity
Kotaro Shobayashi, Jongho Park, Hoshimi Aoyagi, Fumihiko Yasui, Michinori Kohara, Beomjoon Kim · 2025
Read Precision dosing of recombinant vaccinia vaccine via pillar-guided microneedle patch confers SARS-CoV-2 immunity by Kotaro Shobayashi, Jongho Park, Hoshimi Aoyagi, Fumihiko Yasui, Michinori Kohara, Beomjoon Kim (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12749431.txt.
Description
Kotaro Shobayashi and co-authors build, in a 2025 study, a microneedle patch that delivers a precise dose of a COVID-19 vaccine. Patches promise vaccination without deep needles or cold storage chains. Their design adds guide pillars that place the vaccine load exactly, using a recombinant vaccinia virus carrying the coronavirus spike gene as the payload.
Each patch held a high, verified dose of live virus. In mice, the patch raised strong spike-specific antibodies, including neutralizing ones. When the mice were later exposed to the virus, every patched animal survived and held its weight, while control groups fared badly. The authors present the platform as a stable, low-invasive route for vaccination that could be spread widely, including far from central clinics.
Catalog record
| CREATOR | Kotaro Shobayashi, Jongho Park, Hoshimi Aoyagi, Fumihiko Yasui, Michinori Kohara, Beomjoon Kim |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |