Influence of ApoE genotype on doxorubicin-induced cognitive impairment in juvenile rats
Chadni Patel, Frank Diglio, Benjamin H Durham, Peter D Cole · 2025
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Description
Chadni Patel, Frank Diglio, Benjamin Durham, and Peter Cole test whether a known Alzheimer's risk gene also worsens chemotherapy-related memory problems in the young. Many childhood cancer survivors develop cognitive impairment, but not all, hinting at genetic vulnerability. Five-week-old rats carrying either the human ApoE3 or ApoE4 gene variant received the chemotherapy drug doxorubicin or saline for four weeks.
The ApoE4 rats on the drug showed worse visual and spatial memory than every other group. Their brains also grew fewer new neurons in the hippocampus, and a blood marker of brain injury rose. The authors link the genotype's effect to impaired neurogenesis and propose it as groundwork for genotype-specific protective strategies.
Catalog record
| CREATOR | Chadni Patel, Frank Diglio, Benjamin H Durham, Peter D Cole |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |