Canagliflozin restores electrical properties and suppresses structural damage in isoproterenol-induced myocardial injury models
Lisa Kitasato, Yusuke Murayama, Naruya Ishizue, Shuhei Kobayashi, Jun Oikawa, Hidehira Fukaya, Shinichi Niwano, Junya Ako · 2025
Read Canagliflozin restores electrical properties and suppresses structural damage in isoproterenol-induced myocardial injury models by Lisa Kitasato, Yusuke Murayama, Naruya Ishizue, Shuhei Kobayashi, Jun Oikawa, Hidehira Fukaya, Shinichi Niwano, Junya Ako (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12749356.txt.
Description
Lisa Kitasato and co-authors tested a diabetes drug's protective effects on injured hearts in a 2025 study. The drug, canagliflozin, blocks sugar transporters in the kidney and is known to protect the heart, but its effects on heart electricity and structure under stress were unclear. The team used a rat model of drug induced heart injury and heart cells from newborn rats.
The drug blunted the injury's lengthening of electrical signals, cut oxidative stress, preserved the cells' energy factories, and raised ketone levels. In the cells, it improved those energy factories directly, reduced cell death, and turned down several ion handling proteins. Blocking one growth signaling pathway partly erased the benefits. The authors conclude the drug guards the heart by supporting cell energy and steadying calcium handling.
Catalog record
| CREATOR | Lisa Kitasato, Yusuke Murayama, Naruya Ishizue, Shuhei Kobayashi, Jun Oikawa, Hidehira Fukaya, Shinichi Niwano, Junya Ako |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |