Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets
Mengze Wang, Jiafei Lu, Xinyu Li, Huating Xie, Junjie Liang, Jun Luo, Xishu Deng, Guoquan Pan, Bowen Ji, Xiaojie Ding · 2025
Read Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets by Mengze Wang, Jiafei Lu, Xinyu Li, Huating Xie, Junjie Liang, Jun Luo, Xishu Deng, Guoquan Pan, Bowen Ji, Xiaojie Ding (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12749332.txt.
Description
Wang and nine co-authors build an early diagnostic model for pulmonary hypertension from aging-related genes, in a study from twenty twenty-five. The disease raises lung artery pressure toward heart failure silently. Cell aging in vessels is implicated in its development. Multiple data sets are mined for aging-linked gene differences.
Three machine learning methods converge on six hub genes. A nomogram built on them discriminates with excellent accuracy. Three genes verify as lowered in patients and cell models. Immune and oxidative stress pathways enrich around the genes. A candidate compound docks strongly to all three targets.
Catalog record
| CREATOR | Mengze Wang, Jiafei Lu, Xinyu Li, Huating Xie, Junjie Liang, Jun Luo, Xishu Deng, Guoquan Pan, Bowen Ji, Xiaojie Ding |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |