Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma
Ashley Vardon, Scott Haston, Hiba Hamdi, Grace Cooksley, Romain Guiho, Diana Carvalho, Rebecca Carter, Jessica Katherine Rowena Boult, Daniel Gharai, Ielyaas Cloete, James Grey, John Apps, Daohong Zhou, Guangrong Zheng, Ramón Martínez-Máñez, Mark Francis Lythgoe, Laura Kate Donovan, Angel Montero Ca · 2025
Read Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma by Ashley Vardon, Scott Haston, Hiba Hamdi, Grace Cooksley, Romain Guiho, Diana Carvalho, Rebecca Carter, Jessica Katherine Rowena Boult, Daniel Gharai, Ielyaas Cloete, James Grey, John Apps, Daohong Zhou, Guangrong Zheng, Ramón Martínez-Máñez, Mark Francis Lythgoe, Laura Kate Donovan, Angel Montero Ca (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12749289.txt.
Description
Ashley Vardon and co-authors pair a drug with radiation against a deadly childhood brain tumor in a 2025 preclinical study. Diffuse midline gliomas carrying a specific histone mutation resist nearly everything; radiation is the only approved treatment, and relapse is almost certain.
The team found that radiation pushes these tumor cells into senescence, a dormant state, rather than killing them outright. Screening cleanup drugs that remove senescent cells singled out navitoclax, which blocks survival proteins of the Bcl-2 family. Navitoclax drove the dormant cells into apoptosis, working mainly through one family member. Related targeted versions reinforced the effect in the lab models.
Catalog record
| CREATOR | Ashley Vardon, Scott Haston, Hiba Hamdi, Grace Cooksley, Romain Guiho, Diana Carvalho, Rebecca Carter, Jessica Katherine Rowena Boult, Daniel Gharai, Ielyaas Cloete, James Grey, John Apps, Daohong Zhou, Guangrong Zheng, Ramón Martínez-Máñez, Mark Francis Lythgoe, Laura Kate Donovan, Angel Montero Ca |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |