Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth
Anna Maekiniemi, Philipp Savakis, Kelly van Rossum, Jacky L Snoep, Markus Seiler, David D van Niekerk, Kathi Zarnack, Robert H Singer, Evelina Tutucci · 2025
Read Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth by Anna Maekiniemi, Philipp Savakis, Kelly van Rossum, Jacky L Snoep, Markus Seiler, David D van Niekerk, Kathi Zarnack, Robert H Singer, Evelina Tutucci (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12749197.txt.
Description
Clb2 is a conserved B-type cyclin essential for mitotic progression in Saccharomyces cerevisiae, with expression tightly regulated at transcriptional and proteolytic levels. However, it remains unclear whether Clb2 protein synthesis is regulated and responsive to cell growth. Here, we show that CLB2 mRNA localizes to the bud via the She2/She3 complex, while Clb2 protein accumulates in the mother nucleus.
Catalog record
| CREATOR | Anna Maekiniemi, Philipp Savakis, Kelly van Rossum, Jacky L Snoep, Markus Seiler, David D van Niekerk, Kathi Zarnack, Robert H Singer, Evelina Tutucci |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |