Plasma proteomic profiles identify biomarkers predicting Crohn’s disease up to 16 years before onset
Jing Feng, Shuo Chen, Qinming Li, Yu Long, Yuying Ma, Lijun Zhang, Ruijie Zeng, Dongling Luo, Meijun Meng, Shiyi Yu, Chunling Chen, Yanjun Wu, Wentao Huang, Han Zhang, Lingyi Li, Felix W. Leung, Chongyang Duan, Weihong Sha, Hao Chen · 2025
Read Plasma proteomic profiles identify biomarkers predicting Crohn’s disease up to 16 years before onset by Jing Feng, Shuo Chen, Qinming Li, Yu Long, Yuying Ma, Lijun Zhang, Ruijie Zeng, Dongling Luo, Meijun Meng, Shiyi Yu, Chunling Chen, Yanjun Wu, Wentao Huang, Han Zhang, Lingyi Li, Felix W. Leung, Chongyang Duan, Weihong Sha, Hao Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12749172.txt.
Description
Jing Feng and a large team of co-authors show in 2025 that blood protein profiles can predict Crohn's disease years before onset. Reliable early tools for this bowel disease are lacking. They analyzed close to three thousand plasma proteins in a large United Kingdom biobank sample of volunteers.
Forty-four proteins linked to future disease, and nine top proteins fed a machine learning model. The model beat clinical risk models in a separate test region and held up in an outside cohort. Combined with clinical data, it predicted disease up to sixteen years before diagnosis. High-risk people were far more likely to develop the disease.
Catalog record
| CREATOR | Jing Feng, Shuo Chen, Qinming Li, Yu Long, Yuying Ma, Lijun Zhang, Ruijie Zeng, Dongling Luo, Meijun Meng, Shiyi Yu, Chunling Chen, Yanjun Wu, Wentao Huang, Han Zhang, Lingyi Li, Felix W. Leung, Chongyang Duan, Weihong Sha, Hao Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |