Epigenetic and transcriptomic alterations precede amyloidosis in the Alzheimer’s disease AppNL-G-F knock-in mouse model
Mariam Okhovat, Cora E Layman, Brett A Davis, Alexandra Pederson, Abigail O’Niel, Sarah Holden, Kat Kessler, Sonia N Acharya, Kandace J Wheeler, Kimberly A Nevonen, Jarod Herrera, Samantha Ward, Katinka Vigh-Conrad, Andrew Adey, Jacob Raber, Lucia Carbone · 2025
Read Epigenetic and transcriptomic alterations precede amyloidosis in the Alzheimer’s disease AppNL-G-F knock-in mouse model by Mariam Okhovat, Cora E Layman, Brett A Davis, Alexandra Pederson, Abigail O’Niel, Sarah Holden, Kat Kessler, Sonia N Acharya, Kandace J Wheeler, Kimberly A Nevonen, Jarod Herrera, Samantha Ward, Katinka Vigh-Conrad, Andrew Adey, Jacob Raber, Lucia Carbone (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12748836.txt.
Description
Mariam Okhovat and co-authors catch Alzheimer's changes in mouse brains before plaques appear in a 2025 study. They use a knock-in mouse carrying a humanized version of the amyloid gene, which develops amyloid damage on a predictable schedule. Knowing what flips first, before symptoms, is the key to early intervention.
The team profiled the brain and blood at early and later stages on three levels: how open the DNA is, which genes are active, and where chemical tags sit on the DNA. Big gene activity shifts showed up before plaque deposition, even though the hippocampus kept its usual cell mix. Changes in blood hint at early signals that could one day be read without touching the brain. The work maps the disease's opening moves in a faithful model.
Catalog record
| CREATOR | Mariam Okhovat, Cora E Layman, Brett A Davis, Alexandra Pederson, Abigail O’Niel, Sarah Holden, Kat Kessler, Sonia N Acharya, Kandace J Wheeler, Kimberly A Nevonen, Jarod Herrera, Samantha Ward, Katinka Vigh-Conrad, Andrew Adey, Jacob Raber, Lucia Carbone |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |