Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk
Yimeng Wang, Andrey Galkin, Xiaoran Shang, Alexander Marin, Shaohua Jin, Ting-Juan Ye, Shridhar Bale, Chi-I Chiang, Ananda Chowdhury, Agnes L Chenine, Ashley Turonis, Jack Greenhouse, Rebecca Stone, Jaclyn Wear, Swagata Kar, Hanne Andersen, Yan-Jang S Huang, Dana L Vanlandingham, Stephen Higgs, Rena · 2025
Read Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk by Yimeng Wang, Andrey Galkin, Xiaoran Shang, Alexander Marin, Shaohua Jin, Ting-Juan Ye, Shridhar Bale, Chi-I Chiang, Ananda Chowdhury, Agnes L Chenine, Ashley Turonis, Jack Greenhouse, Rebecca Stone, Jaclyn Wear, Swagata Kar, Hanne Andersen, Yan-Jang S Huang, Dana L Vanlandingham, Stephen Higgs, Rena (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12748774.txt.
Description
Yimeng Wang and co-authors design a flavivirus vaccine that aims to avoid a dangerous antibody side effect, in a 2025 paper. Flaviviruses include dengue, Zika, and yellow fever viruses. Vaccines against one member can worsen disease from a cousin. That antibody-dependent enhancement has long haunted vaccine design.
The team changed two spots in the viral envelope protein. The swaps force the protein into paired dimers. That shape should focus the immune response on safer targets. Tests checked both the strength of protection and the enhancement risk. The design held up well on both counts. A platform that suits many flaviviruses at once is the prize. Tropical disease programs stand to gain most.
Catalog record
| CREATOR | Yimeng Wang, Andrey Galkin, Xiaoran Shang, Alexander Marin, Shaohua Jin, Ting-Juan Ye, Shridhar Bale, Chi-I Chiang, Ananda Chowdhury, Agnes L Chenine, Ashley Turonis, Jack Greenhouse, Rebecca Stone, Jaclyn Wear, Swagata Kar, Hanne Andersen, Yan-Jang S Huang, Dana L Vanlandingham, Stephen Higgs, Rena |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 95 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |