Distinct mechanisms of transcriptomic habituation to repeated stress in the mouse hippocampus
Rebecca Waag, Lukas von Ziegler, Emanuel Sonder, Oliver Sturman, Justine Leonardi, Selina Frei, Rosie Longster, Katharina Gapp, Pierre-Luc Germain, Johannes Bohacek · 2025
Read Distinct mechanisms of transcriptomic habituation to repeated stress in the mouse hippocampus by Rebecca Waag, Lukas von Ziegler, Emanuel Sonder, Oliver Sturman, Justine Leonardi, Selina Frei, Rosie Longster, Katharina Gapp, Pierre-Luc Germain, Johannes Bohacek (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12748579.txt.
Description
Waag and nine co-authors study how mouse brain gene activity adapts to repeated stress, in a study from twenty twenty-five. Chronic stress raises risk for mental illness, so adaptation matters for health. It was unclear whether brains simply blunt their response or build a new one. The team restrains mice repeatedly and reads genes in the lower hippocampus.
Across many time points, stress-driven gene changes grow blunt with repetition. No new response pattern emerges, and resting gene levels stay flat. Single-cell reads confirm blunting across all cell types, with cell-specific twists. Two mechanisms stand out, one via fewer activated cells and one via shorter responses. An interactive app shares the full resource.
Catalog record
| CREATOR | Rebecca Waag, Lukas von Ziegler, Emanuel Sonder, Oliver Sturman, Justine Leonardi, Selina Frei, Rosie Longster, Katharina Gapp, Pierre-Luc Germain, Johannes Bohacek |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |