GRB10 as a pan-cancer biomarker linking oncogenic signaling, immunosuppression, and immunotherapy resistance
Haoran Guo, Junjie Chen · 2025
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Description
A helper protein that tunes growth signals may also help cancers dodge the immune system, making it a possible marker across many tumor types. Haoran Guo and Junjie Chen mapped that protein role across cancers in this 2025 study. They mined multi-layer data from thirty-three cancer types in a large public atlas and checked findings in other cohorts.
The protein ran high in eleven cancer types and low in four others. High levels often went with worse survival in several cancers, including a brain tumor type. The team also linked the protein to immune cell mix in tumors and to how well immune drugs might work. A single marker tied to growth, immune escape, and drug response could help doctors sort patients, though lab proof must follow.
Catalog record
| CREATOR | Haoran Guo, Junjie Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |