Next-generation cell lines for profiling different proteasome forms and their implications in cancer
Alexander Burov, Anastasia Yakovleva, Georgy Linovskiy, Andrei Fedotov, Vladimir Popenko, Olga Leonova, Aleksandr Lanin, Marina Drutskaya, Vadim Karpov, Alexey Morozov · 2025
Read Next-generation cell lines for profiling different proteasome forms and their implications in cancer by Alexander Burov, Anastasia Yakovleva, Georgy Linovskiy, Andrei Fedotov, Vladimir Popenko, Olga Leonova, Aleksandr Lanin, Marina Drutskaya, Vadim Karpov, Alexey Morozov (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12748260.txt.
Description
Alexander Burov and nine co-authors present a 2025 paper on engineered cancer cell lines that let researchers watch the cell's protein shredders at work. Proteasomes come in several forms, standard, immune, and mixed, built from different catalytic parts. The forms shape metabolism, immune signaling, and tumor growth, but telling them apart inside cells is hard. The team used gene editing to tag three different subunits with glowing proteins in two cancer cell lines.
The tags lit up without breaking the machines, letting the forms be followed under the microscope. One tag could be switched by light, revealing immune and mixed proteasomes inside the nucleus after immune signals. In mouse tumors, regions rich in one form appeared and seemed able to leave the cells. The authors offer the lines as tools for profiling proteasome forms in cancer.
Catalog record
| CREATOR | Alexander Burov, Anastasia Yakovleva, Georgy Linovskiy, Andrei Fedotov, Vladimir Popenko, Olga Leonova, Aleksandr Lanin, Marina Drutskaya, Vadim Karpov, Alexey Morozov |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |