Nature’s cryptographic codebreaker: in silico decoding of apigenin’s triple defense against SARS-CoV-2
Juanjuan Huang, Yabo Fang, Hongya Guan, Shoukui Hu · 2025
Read Nature’s cryptographic codebreaker: in silico decoding of apigenin’s triple defense against SARS-CoV-2 by Juanjuan Huang, Yabo Fang, Hongya Guan, Shoukui Hu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12748202.txt.
Description
Juanjuan Huang, Yabo Fang, Hongya Guan, and Shoukui Hu test apigenin, a plant flavonoid, as a three-front candidate against the COVID virus, entirely in the computer. Broad antivirals that strike both viral and host targets are prized after the pandemic's lesson. Apigenin already shows antiviral and calming traits, but its worth here was unmapped.
Their 2025 study chains prediction models, docking, and network pharmacology into one screen. A graph model first flags apigenin as a plausible drug for the virus. Docking then shows firm binding to a host stress protein and a cell-surface sugar chain, plus a viral enzyme. The authors read the triple grip as a defense worth taking to wet-lab tests.
Catalog record
| CREATOR | Juanjuan Huang, Yabo Fang, Hongya Guan, Shoukui Hu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |