IL-18 receptor axis in allergic conjunctivitis: a multi-omics study
Liyun Yuan, Wangming Su, Liangpin Li, Yang Xiang, Zijiao Xu, Yuchuan Wang, Xia Hua, Xiaoyong Yuan · 2025
Read IL-18 receptor axis in allergic conjunctivitis: a multi-omics study by Liyun Yuan, Wangming Su, Liangpin Li, Yang Xiang, Zijiao Xu, Yuchuan Wang, Xia Hua, Xiaoyong Yuan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12748174.txt.
Description
Liyun Yuan and co-authors report a 2025 study of allergic eye disease. The classic account centers on one helper cell type. That account does not fully explain the disease. The team joins several data types to hunt for genes and immune paths. They focus on a receptor axis for a signal called IL-18. Human gene data and mouse single-cell data are combined.
Three gene-scan methods found nine strong candidate genes. Several sit in two known defense signal families. Single-cell data from a mouse model mapped how immune cells talk to each other. A second mouse model checked the key paths with lab tests and clinical scores. Eye doctors get candidate genes that may explain why cases differ so much. New targets could guide drugs for patients whom standard allergy care fails. The work joins human genetics with mouse proof in one arc.
Catalog record
| CREATOR | Liyun Yuan, Wangming Su, Liangpin Li, Yang Xiang, Zijiao Xu, Yuchuan Wang, Xia Hua, Xiaoyong Yuan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |