Different beta-blockers for preventing arrhythmic events in patients with long QT syndrome: a network meta-analysis
Youxu Jiang, Lihua Zhang, Haiyan Xiong, Yuan Li, Chang Su, Mingna Zhu, Yinchuan Zhu · 2025
Read Different beta-blockers for preventing arrhythmic events in patients with long QT syndrome: a network meta-analysis by Youxu Jiang, Lihua Zhang, Haiyan Xiong, Yuan Li, Chang Su, Mingna Zhu, Yinchuan Zhu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12748156.txt.
Description
Youxu Jiang and co-authors compare beta-blocker drugs for a heart rhythm disorder in this 2025 paper. In long QT syndrome, the heart's reset takes too long, raising the risk of dangerous rhythms. Beta-blockers are the standard guard, but which one works best, and at what dose, was unsettled.
The team pooled ten cohort studies with 5,692 patients and modeled dose as a sliding factor. For the first genetic type, nadolol beat propranolol and ranked most likely best. For the second and third types, no drug clearly beat the others, though nadolol and propranolol ranked highest. Dose effects were mostly absent, except for nadolol in two types. The authors frame the rankings as guidance, not proof.
Catalog record
| CREATOR | Youxu Jiang, Lihua Zhang, Haiyan Xiong, Yuan Li, Chang Su, Mingna Zhu, Yinchuan Zhu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |