Acute Drug-Induced Hepatitis Associated With Vortioxetine: A Case Report
Carolina Guimarães, Rui Ribeiro, Helena Hipólito Reis, Ana Ribeiro, Jorge S Almeida · 2025
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Description
Carolina Guimarães and co-authors report a case of liver injury caused by the antidepressant vortioxetine. Their 2025 case report describes a fifty-nine-year-old woman who developed acute hepatitis with bile-flow features after long use of the drug. Such liver harm from this medicine is rarely reported.
Tests ruled out viral, autoimmune, and metabolic causes. Her liver improved once the drug stopped, then worsened when it was restarted, sealing the link. A later reaction to venlafaxine suggested sensitivity across this drug family. She recovered after stopping antidepressants and receiving a protective agent. The authors remind prescribers to weigh liver injury in patients on these drugs.
Catalog record
| CREATOR | Carolina Guimarães, Rui Ribeiro, Helena Hipólito Reis, Ana Ribeiro, Jorge S Almeida |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |