Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core
Haidara Nadwa, Z. Faidon Brotzakis, Annalisa Santucci, Daniela Braconi, Michele Vendruscolo · 2025
Read Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core by Haidara Nadwa, Z. Faidon Brotzakis, Annalisa Santucci, Daniela Braconi, Michele Vendruscolo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12746452.txt.
Description
Haidara Nadwa and four co-authors trace the first steps of a disease protein's misfolding in a 2025 paper. The protein is the main precursor of a serious amyloid disease, but the earliest trigger was unclear. Using two advanced simulation methods, they watched a disease-relevant fragment of it move over long simulated times and many temperatures. The free-energy maps told a clear story.
One helix came undone first, before the others loosened, while the whole bundle stayed compact. During that stage, a hidden aggregation-prone stretch briefly surfaced. The authors argue that this local exposure, not full unfolding, starts the disease process, and they name stabilizing that helix as a drug strategy.
Catalog record
| CREATOR | Haidara Nadwa, Z. Faidon Brotzakis, Annalisa Santucci, Daniela Braconi, Michele Vendruscolo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |