Recruiting ESCRT to single-chain heterotrimer peptide MHCI releases antigen-presenting vesicles that stimulate T cells selectively
Blade A. Olson, Kathryn E. Huey-Tubman, Zhiyuan Mao, Magnus A. G. Hoffmann, Pamela J. Bjorkman, Richard M. Murray, Stephen L. Mayo · 2025
Read Recruiting ESCRT to single-chain heterotrimer peptide MHCI releases antigen-presenting vesicles that stimulate T cells selectively by Blade A. Olson, Kathryn E. Huey-Tubman, Zhiyuan Mao, Magnus A. G. Hoffmann, Pamela J. Bjorkman, Richard M. Murray, Stephen L. Mayo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12745732.txt.
Description
Blade Olson and six co-authors published an immunology study in twenty twenty-five on manufacturing tiny vesicles that present antigens to T cells. Immune cells naturally release such vesicles, which can start, expand, or quiet immune responses. Making them artificially could yield cell-free immunotherapies, but production had been cumbersome.
The team engineered ordinary cells to build and shed the vesicles. A peptide-MHC construct carried an added tail piece that recruits the cell's ESCRT machinery, which buds vesicles off the surface. The trick worked across several constructs. Purified vesicles triggered interferon release only from T cells matching their displayed antigen, showing selective stimulation.
Catalog record
| CREATOR | Blade A. Olson, Kathryn E. Huey-Tubman, Zhiyuan Mao, Magnus A. G. Hoffmann, Pamela J. Bjorkman, Richard M. Murray, Stephen L. Mayo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |