Physical exercise increases binding of POMC to blood extracellular vesicles
Mark F. Santos, Jacqueline Randa, Derek Tai, Giulio Vistoli, Nofar Avihen Schahaf, Serena Vittorio, Geily Fuentes, Rita Lauro, Sheila Mosallaei, Jana Karbanová, Alexandra M. K. Yokomizo, Denis Corbeil, Cheryl E. Hightower, Aurelio Lorico · 2025
Read Physical exercise increases binding of POMC to blood extracellular vesicles by Mark F. Santos, Jacqueline Randa, Derek Tai, Giulio Vistoli, Nofar Avihen Schahaf, Serena Vittorio, Geily Fuentes, Rita Lauro, Sheila Mosallaei, Jana Karbanová, Alexandra M. K. Yokomizo, Denis Corbeil, Cheryl E. Hightower, Aurelio Lorico (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12745691.txt.
Description
Santos and co-authors show that exercise sends a hormone precursor hitching rides on tiny blood particles, in a 2025 study. The precursor, POMC, is chopped into hormones that govern energy, stress, and pain. The team found full-length POMC binding to small extracellular vesicles, bubble-like packets cells shed into blood. In healthy adults, the vesicle-bound share of POMC rose fourfold after intense exercise, while total levels stayed flat.
The loaded vesicles carried markers of blood cells and platelets, and many vesicles bore the very receptors POMC products act on. Binding tightened under acidic conditions, matching a shape change in the protein. Loaded vesicles triggered pigment production in melanoma cells and crossed a model blood-brain barrier faster than free POMC.
Catalog record
| CREATOR | Mark F. Santos, Jacqueline Randa, Derek Tai, Giulio Vistoli, Nofar Avihen Schahaf, Serena Vittorio, Geily Fuentes, Rita Lauro, Sheila Mosallaei, Jana Karbanová, Alexandra M. K. Yokomizo, Denis Corbeil, Cheryl E. Hightower, Aurelio Lorico |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |