Convergent mutation trajectories convert functional self-tolerance in IGHV4-34 B cells to genetic tolerance encoded in the antibody
Christopher J. Jara, Sherin Zachariah, Katherine J. L. Jackson, Timothy J. Peters, Etienne Masle-Farquhar, Deborah L. Burnett, Eric Lam, Megan Faulks, Amanda Russell, Lisa Miosge, Stewart Smith, David C. Tscharke, Robert Brink, Christopher C. Goodnow, Joanne H. Reed · 2025
Read Convergent mutation trajectories convert functional self-tolerance in IGHV4-34 B cells to genetic tolerance encoded in the antibody by Christopher J. Jara, Sherin Zachariah, Katherine J. L. Jackson, Timothy J. Peters, Etienne Masle-Farquhar, Deborah L. Burnett, Eric Lam, Megan Faulks, Amanda Russell, Lisa Miosge, Stewart Smith, David C. Tscharke, Robert Brink, Christopher C. Goodnow, Joanne H. Reed (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12745689.txt.
Description
Some antibody-making cells carry a self-targeting part yet stay silent, and Christopher Jara and co-authors asked why the body keeps such cells, in work from twenty twenty-five. The cells use one heavy chain part found in a fair share of human blood cells. In mice built to copy the setup, the cells were hushed: low surface flags, no entry to key zones, and no antibody release.
A virus that the cells also matched broke the hush. In germ centers the cells changed fast, and near all daughter cells picked up one of five changes within weeks. Those changes cut self-binding while keeping virus binding. A third had stacked two or three changes and turned fully safe. The work shows how virus response can sculpt safe, sharp antibodies.
Catalog record
| CREATOR | Christopher J. Jara, Sherin Zachariah, Katherine J. L. Jackson, Timothy J. Peters, Etienne Masle-Farquhar, Deborah L. Burnett, Eric Lam, Megan Faulks, Amanda Russell, Lisa Miosge, Stewart Smith, David C. Tscharke, Robert Brink, Christopher C. Goodnow, Joanne H. Reed |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |