Single-nucleus RNA-seq reveals no increase in T cells in Alzheimer’s disease prefrontal cortex or hippocampus
Jake D. Oxendine, Daniel W. Sirkis, Caroline Jonson, Jennifer S. Yokoyama · 2025
Read Single-nucleus RNA-seq reveals no increase in T cells in Alzheimer’s disease prefrontal cortex or hippocampus by Jake D. Oxendine, Daniel W. Sirkis, Caroline Jonson, Jennifer S. Yokoyama (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12745470.txt.
Description
Jake Oxendine, Daniel Sirkis, Caroline Jonson, and Jennifer Yokoyama present a 2025 study challenging claims that T cells flood the Alzheimer's brain. Earlier work had reported more of these immune cells in affected tissue, suggesting immune crosstalk drives the disease. The team mined single-nucleus sequencing from the largest postmortem Alzheimer's cohort, checking two regions: the prefrontal cortex and the hippocampus.
They found no significant increase in T cell share in confirmed Alzheimer's cases in either region. A second large atlas agreed for the prefrontal cortex. One earlier finding, T cell expansion in a temporal region, did replicate, though donor age weakened it. Gene activity inside the T cells also looked unchanged. The authors conclude the enrichment is local, not brain-wide, and warn that region choice and data composition shape such conclusions.
Catalog record
| CREATOR | Jake D. Oxendine, Daniel W. Sirkis, Caroline Jonson, Jennifer S. Yokoyama |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |