Autophagic regulation of CD8+ T cell metabolic reprogramming defines acute and latent phases of cytomegalovirus infection in vivo
Hui Liu, Xiaobing Liu, Wai Ho Oscar Yeung, Jiang Liu, Kevin Tak Pan Ng, Kwan Man · 2025
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Description
Hui Liu and co-authors follow killer T cells through a cytomegalovirus infection in rats in a 2025 study. The virus hides in the body for life and can wake up when immunity drops, so knowing how T cells adapt matters. The team infected healthy rats and tracked one cell process, autophagy, where cells recycle their own parts, alongside fuel-use markers in the T cells.
T cell numbers peaked near week three and settled back by week six. Their recycling activity rose and fell on the same schedule, and two fuel markers moved with it. In dish tests, drugs that block or boost recycling shifted those markers directly. The authors conclude that recycling steers how these T cells refuel across the active and quiet phases, and they offer the rat model for further work on the virus's hidden phase.
Catalog record
| CREATOR | Hui Liu, Xiaobing Liu, Wai Ho Oscar Yeung, Jiang Liu, Kevin Tak Pan Ng, Kwan Man |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |