Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer
Tae-Young Jang, So-El Jeon, Hyeon-Ji Yun, Choong-Jae Lee, Da-Ye Lim, Sang Hoon Lee, Dajun Lee, Seungwon Lee, Jungmin Choi, Hyung-Sik Kim, Jeong-Seok Nam · 2025
Read Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer by Tae-Young Jang, So-El Jeon, Hyeon-Ji Yun, Choong-Jae Lee, Da-Ye Lim, Sang Hoon Lee, Dajun Lee, Seungwon Lee, Jungmin Choi, Hyung-Sik Kim, Jeong-Seok Nam (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12745361.txt.
Description
Liver cancer resists both chemotherapy and immune therapy, and a sticky cell-surface protein may be coordinating the defense. Tae-Young Jang and co-authors name that protein, dysadherin, in a 2025 study linking it to stem-like behavior and immune escape.
Working from single-cell data, dish experiments, and mouse models including one with a human-like immune system, the team traced a signaling chain from dysadherin through to a growth switch. The chain switched on stemness genes and raised the PD-L1 shield that hides tumors from T cells. Blocking dysadherin, by gene silencing or a peptide drug, woke the immune attack back up and slowed spread. The axis offers a fresh target for stubborn liver tumors.
Catalog record
| CREATOR | Tae-Young Jang, So-El Jeon, Hyeon-Ji Yun, Choong-Jae Lee, Da-Ye Lim, Sang Hoon Lee, Dajun Lee, Seungwon Lee, Jungmin Choi, Hyung-Sik Kim, Jeong-Seok Nam |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |