Early start of opicapone in Parkinson’s disease: evidence from a pooled analysis of phase 3 trials for sustained benefit in patients with recent onset of motor fluctuations
Joaquim J. Ferreira, Fabrizio Stocchi, Angelo Antonini, Olivier Rascol, Georg Ebersbach, Jaime Kulisevsky, Miguel M. Fonseca, Daniel Ramos, José Francisco Rocha, Helena C. Brigas, Joerg Holenz, Werner Poewe · 2025
Read Early start of opicapone in Parkinson’s disease: evidence from a pooled analysis of phase 3 trials for sustained benefit in patients with recent onset of motor fluctuations by Joaquim J. Ferreira, Fabrizio Stocchi, Angelo Antonini, Olivier Rascol, Georg Ebersbach, Jaime Kulisevsky, Miguel M. Fonseca, Daniel Ramos, José Francisco Rocha, Helena C. Brigas, Joerg Holenz, Werner Poewe (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12745269.txt.
Description
Joaquim Ferreira and co-authors pool two trials to test early use of a Parkinson's drug that extends levodopa action. Their 2025 analysis covers patients whose motor swings began within the prior two years. Levodopa is the main therapy, but long use brings daily off periods.
More than two hundred patients from blind trials and year-long open follow-ups took part. The drug cut daily off time by about an hour versus placebo and added good on time. Patients who switched later from placebo improved as well. Yet those who began early kept a small numeric edge at the end of the open phase. The authors read the data as support for starting at the onset of swings, not waiting.
Catalog record
| CREATOR | Joaquim J. Ferreira, Fabrizio Stocchi, Angelo Antonini, Olivier Rascol, Georg Ebersbach, Jaime Kulisevsky, Miguel M. Fonseca, Daniel Ramos, José Francisco Rocha, Helena C. Brigas, Joerg Holenz, Werner Poewe |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |