Food-specific IgG-based elimination diet decreased IL-6, TNF-α, and CGRP and improved symptoms in adults with migraine
Zhiming Zhao, Meimei Yang, Fujun Wan, Baoli Ning, Tao Song, Jun Fu, Liming Zhang · 2025
Read Food-specific IgG-based elimination diet decreased IL-6, TNF-α, and CGRP and improved symptoms in adults with migraine by Zhiming Zhao, Meimei Yang, Fujun Wan, Baoli Ning, Tao Song, Jun Fu, Liming Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12745268.txt.
Description
Zhiming Zhao and six co-authors test a migraine diet that bans foods flagged by each patient's own antibody tests, in a two thousand twenty-five randomized trial. Food-specific IgG antibodies are proposed markers of inflammatory food triggers.
Ninety-eight migraine patients with at least one positive food IgG were split between true elimination and a sham diet excluding antibody-negative foods instead. After twelve weeks the true group improved more on migraine, gut symptoms, and sleep questionnaires, and their positive IgG counts fell. Inflammatory messengers interleukin-6, tumor necrosis factor alpha, and the pain peptide CGRP also dropped. Adjusting for the cytokines shrank the migraine benefit, implicating inflammation as the mechanism.
Catalog record
| CREATOR | Zhiming Zhao, Meimei Yang, Fujun Wan, Baoli Ning, Tao Song, Jun Fu, Liming Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |