Ameliorative effects and mechanism of Panax notoginseng extract on ulcerative colitis mice based on a multi-omics strategy
Yan Song, Rui Lin, Yifeng Fu, Anna Wang, Hu Yang, Wentian Liu · 2025
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Description
Yan Song and co-authors test a classic herbal extract against ulcerative colitis in mice. Their 2025 study uses Panax notoginseng, a ginseng relative long used in Chinese medicine, in animals whose colons were inflamed by a chemical trigger that mimics the human disease.
Treated mice showed a repaired gut barrier, with the seal proteins between cells restored. Their gut microbe mix also shifted toward balance, with more of two friendly bacterial groups. Waste chemicals in the stool tied to the disease fell. By layering gene, microbe, and chemistry data, the team mapped a web linking microbes, metabolites, and barrier strength. They conclude the extract calms colitis through several targets at once.
Catalog record
| CREATOR | Yan Song, Rui Lin, Yifeng Fu, Anna Wang, Hu Yang, Wentian Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |