Heat shock proteins in osteoarthritis: molecular mechanisms, pathogenic roles, and therapeutic opportunities
Bin Zhao, Zhijun Deng, Zhijun Yang, Fengyun Yang, Wenlong Yang · 2025
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Description
Bin Zhao and co-authors review heat shock proteins in osteoarthritis in two thousand twenty-five. These proteins act as chaperones that fold other proteins and guard cells under stress. In worn joints, several family members are out of balance, feeding inflammation, cartilage breakdown, and death of cartilage cells, yet at times protecting them.
That double role makes the proteins both markers of disease activity and candidate drug targets. The review maps how the main family members steer cell death, self-cleaning, and inflammatory signaling in joint tissues. It then surveys ways to tune them: drugs, natural products, nano-medicine, stem cells, physical treatments such as heat and ultrasound, and antibody agents. The authors argue such targeting could slow joint damage and preserve cartilage cell function.
Catalog record
| CREATOR | Bin Zhao, Zhijun Deng, Zhijun Yang, Fengyun Yang, Wenlong Yang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 109 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |